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Resveratrol

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Related terms
Background
Evidencetable
Tradition
Dosing
Attribution
Bibliography

Related Terms
  • Ban-ji-ryun, ban-zhi-lian, banjiryun, Belamcanda chinensis, bergenin, betulin, betulinic acid, cis-piceid, cis-resveratrol (cis-3,4,5- trihydroxystilbene), Cissus quadrangularis, Elephantorrhiza goetzei, epsilon-Viniferin (a dimer of resveratrol), Erythrophleum lasianthum (Caesalpinioidae, Leguminosae), flavanoid, French paradox, gnetin H (a resveratrol analog), Gnetum montanum, grape seed proanthycyanidin extract (GSPE), grape skin, heyneanol A (a resveratrol tetramer), hydroxystilbene, ko-jo-kon, Liliaceae, lyophilized grape powder (LGP), mangiferonic acid, non-flavanoid polyphenol, Paeonia lactiflora Pall. (Paeoniaceae), pallidol, parthenocissine A, phenolic antioxidant, phytoalexin, phytoantitoxin, phytoestrogens, phytohormones, phytostilbene, piceatannol, Polygonum cuspidatum, polyphenol, prenylflavanone, protykin, quadrangularin, red wine, red wine polyphenol, RESV, resverol, resveratrol 3-O-beta-D-glucopyranoside, Reynoutria japonica, Scutellaria barbata D. Don (Lamiaceae), Sophora moorcroftiana Benth., Sophora tomentosa L., stilbene, stilbene derivative resveratrol (RES), stilbene polyphenol, stilbenoid, suffruticosol B (a resveratrol analog), trans-3,4',5-trihydroxystilbene, trans-piceid, trans-resveratrol, transhydroxystilbene, tyrphostin, vatdiospyroidol (a resveratrol tetramer), Vaticapauciflora, Vatica rassak (Dipterocarpaceae), vaticanol C (a resveratrol tetramer), vaticaphenol A, Veratrum taliense, viniferin (a resveratrol analog), Vitis vinifera L.

Background
  • Resveratrol is found in over 70 plant species including nuts, grapes, pine trees, certain vines, and red wine. Some experts believe that resveratrol may be a factor in the French paradox that coronary heart disease mortality in France is lower than other similar industrialized countries due to the frequent consumption of red wine.
  • Resveratrol has been shown in animal and laboratory studies to exhibit antioxidant, anticancer, antiproliferative, antifungal, antiviral, and antibacterial effects. However, data in humans is lacking.
  • At this time, there is a lack of high quality human trials available supporting the efficacy of resveratrol for any indication. However, there are several observational studies that correlate the consumption of wine with a decrease in cancer and/or cardiovascular disease risk. There are multiple possible contributing factors to these conditions, and studies of resveratrol are difficult to design and implement. Too much alcohol intake can be dangerous. Further research is needed before a firm recommendation can be made.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


The effects of resveratrol cannot be adequately assessed from trials using foods, wine, or combination products containing resveratrol and other substances. Well-designed clinical trials of resveratrol alone are needed before a recommendation can be made in regards to cancer prevention and/or treatment.

C


The effects of resveratrol cannot be adequately assessed from trials using foods, wine, or combination products containing resveratrol and other substances. Well-designed clinical trials of resveratrol alone are needed before a recommendation can be made.

C


Resveratrol has been included in herbal products that are marketed to increase lifespan and prevent aging. Limited evidence shows a possible benefit for this use, but more studies are needed in this area.

C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)


Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

  • Age-related macular degeneration, allergy, Alzheimer's disease, amyloidosis, amyotrophic lateral sclerosis, antifungal, anti-inflammatory, antimicrobial, antioxidant, antiplatelet, anti-tumor agent, antiviral, atherosclerosis, bone density, cancer prevention, cerebral ischemia, chemoprotectant, chronic obstructive pulmonary disease (COPD), cognitive disorders, cosmetic, degenerative diseases, diabetic neuropathy, diabetic wound healing, edema, Epstein-Barr virus, hearing loss, infection, herpes simplex virus types 1 and 2, HIV, hormonal imbalances, hypercholesterolemia, immunomodulator, influenza, ischemia-reperfusion injury prevention, leukemia, medulloblastoma, menopausal symptoms, multiple sclerosis, nephrotoxicity, neuroblastoma, neuropathy, neuroprotection, pain, pancreatitis, Parkinson's disease, premature aging, renal impairment (protection), rheumatoid arthritis, seizure, skin disorders, spinal cord injury, stroke, vascular diseases, vasorelaxant, wound healing.

Dosing

Adults (over 18 years old)

  • Insufficient available evidence.

Children (under 18 years old)

  • Insufficient available evidence.

Attribution
  • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography
  1. Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006 May 14;71(10):1397-421.
  2. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006 Jun;5(6):493-506.
  3. Cheong H, Ryu SY, Kim KM. Anti-allergic action of resveratrol and related hydroxystilbenes. Planta Med 1999;65(3):266-268.
  4. Cruz MN, Luksha L, Logman H, et al. Acute responses to phytoestrogens in small arteries from men with coronary heart disease. Am J Physiol Heart Circ Physiol 2006 May;290(5):H1969-75.
  5. Delmas D, Lancon A, Colin D, et al. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets 2006 Apr;7(4):423-42.
  6. Gronbaek M, Deis A, Sorensen TI, et al. Mortality associated with moderate intakes of wine, beer, or spirits. BMJ 5-6-1995;310(6988):1165-1169.
  7. Labinskyy N, Csiszar A, Veress G, et al. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr Med Chem 2006;13(9):989-96.
  8. Lekakis J, Rallidis LS, Andreadou I, et al. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil 2005 Dec;12(6):596-600.
  9. Levi F, Pasche C, Lucchini F, et al. Resveratrol and breast cancer risk. Eur.J Cancer Prev 2005;14(2):139-142.
  10. Rainsford KD. Influenza ("Bird Flu"), inflammation and anti-inflammatory/analgesic drugs. Inflammopharmacology 2006 Mar;14(1-2):2-9.
  11. Rahman I, Kilty I. Antioxidant therapeutic targets in COPD. Curr Drug Targets 2006 Jun;7(6):707-20.
  12. Rakici O, Kiziltepe U, Coskun B, et al. Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery. Int J Cardiol 2005 Nov 2;105(2):209-15.
  13. Truelsen T, Gronbaek M, Schnohr P, et al. Intake of beer, wine, and spirits and risk of stroke: the Copenhagen city heart study. Stroke 1998;29(12):2467-2472.
  14. Zern TL, Wood RJ, Greene C, et al. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr 2005;135(8):1911-1917.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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